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KMID : 1134820180470111085
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 11 p.1085 ~ p.1092
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Anti-Oxidant and Inhibitory Activities on Elastase, Collagenase, Hyaluronidase, and α-Glucosidase of Cedrela sinensis Fruits
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Lim Su-Bin
Kim Myung-Uk
Lee Eun-Ho
Kim Ye-Jin
Cho Eun-Bi
Park Kyeung-Il
Kang In-Kyu
Cho Young-Je
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Abstract
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This study examined the anti-oxidation and inhibitory activities of extracts from Cedrela sinensis fruits on elastase, collagenase, hyaluronidase, and α-glucosidase. The total phenolics content (TPC) of C. sinensis fruits was 56.54 mg/g in the hot water extracts and 104.94 mg/g in the 50% ethanol extracts, which was the highest. The TPC in the freeze-dried powder of the hot water extracts and the 50% ethanol extracts were 390.73 and 491.47 mg/g, respectively. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities of the C. sinensis fruits water extract powder (CSWP) and C. sinensis fruits ethanol extract powder (CSEP) were 72.17 and 71.38% at a 200 μg/mL concentration, respectively. The 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization of CSWP and CSEP were 99.11 and 99.16%, respectively, at 200 μg/mL. The anti-oxidant protection factors (PF) of CSWP and CSEP were 1.75 and 1.91 PF, respectively, at 200 μg/mL. The thiobarbituric acid reactive substances (TBARS) of CSWP and CSEP were 38.72% and 56.95%, respectively, at 200 μg/mL. The DPPH and ABTS of CSWP and CSEP were higher than those of butylated hydroxytoluene (BHT), but PF and TBARS were lower than those of BHT. The elastase inhibitory activity of CSWP was not observed but the inhibitory activity of CSEP was 85.28% at 200 μg/mL. The collagenase inhibitory activity of CSWP and CSEP were 29.38% and 56.66%, respectively, at 200 μg/mL. Therefore, CSP was considered to be a potential source of cosmetic products for the wrinkle-improving function. The hyaluronidase (HAase) inhibitory activity of CSWP and CSEP as the biological activity for functional food were 87.80% and 88.51%, respectively, at 200 μg/mL. The α-glucosidase inhibitory activity of CSWP and CSEP were 92.17% and 99.06%, respectively, at 200 μg/mL. CSWP and CSEP were similar or more effective than EGCG as a positive control. The CSP showed excellent of anti-oxidant, anti-wrinkle, and anti-inflammation activities and helped decrease the blood sugar content through the glucosidase inhibition activity. These results show that extracts from C. sinensis can be used as a functional resource with anti-oxidant, anti-wrinkle, anti-inflammation, and anti-diabetes activities.
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KEYWORD
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anti-oxidant, Cedrela sinensis fruits, enzyme inhibition, freeze-dried powder
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